Maternal antibody interference contributes to reduced rotavirus vaccine efficacy in developing countries

Rotavirus vaccine--a need of the hour in developing countries.

Rotavirus vaccine efficacy in African and Asian countries.

The report by George Armah and colleagues (Aug 21, p 606) on the effi cacy of a pentavalent rotavirus vaccine in sub-Saharan Africa is encouraging news for the control of rotavirus gastroenteritis in African children. Interestingly, the same vaccine is about 50% less effi cacious than reported in some developed countries. Although the absolute proportion of severe diarrhoeal disease prevented i...

Understanding Reduced Rotavirus Vaccine Efficacy in Low Socio-Economic Settings

INTRODUCTION Rotavirus vaccine efficacy ranges from >90% in high socio-economic settings (SES) to 50% in low SES. With the imminent introduction of rotavirus vaccine in low SES countries, understanding reasons for reduced efficacy in these settings could identify strategies to improve vaccine performance. METHODS We developed a mathematical model to predict rotavirus vaccine efficacy in high,...

Rotavirus vaccination in developing countries.

Although two oral rotavirus vaccines are licensed in many countries, multiple factors may affect decision-making regarding introduction into national immunization programs in developing countries. Financial and logistic challenges to introduction of rotavirus vaccines in countries with limited infrastructure and resources are accompanied by a perceived lack of need and evidence from recent vacc...

Use of formative research in developing a knowledge translation approach to rotavirus vaccine introduction in developing countries

BACKGROUND Rotavirus gastroenteritis is the leading cause of diarrheal disease mortality among children under five, resulting in 450,000 to 700,000 deaths each year, and another 2 million hospitalizations, mostly in the developing world. Nearly every child in the world is infected with rotavirus at least once before they are five years old. Vaccines to prevent rotavirus or minimize its severity...